Abstract
A series of benzofused sultams and fluorinated benzenesulfonamides were synthesized in superacid HF/SbF(5) from simple N-allylic derivatives. Almost all of these original compounds showed micromolar inhibitory activities against carbonic anhydrases I and II. The fluorinated derivatives inhibit better the tumor-associated isoforms IX and XII, and one of the tested compounds showed inhibition in the nanomolar range.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimony / chemistry*
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Carbonic Anhydrase Inhibitors / chemical synthesis*
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Carbonic Anhydrase Inhibitors / chemistry
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Carbonic Anhydrases / chemistry*
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Fluorides / chemistry*
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Halogenation
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Humans
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Hydrofluoric Acid / chemistry*
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Isoenzymes / antagonists & inhibitors
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Isoenzymes / chemistry
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Kinetics
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Magnetic Resonance Spectroscopy
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Neoplasm Proteins / antagonists & inhibitors*
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Neoplasm Proteins / chemistry
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Solutions
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Sulfonamides / chemical synthesis*
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Sulfonamides / chemistry
Substances
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Carbonic Anhydrase Inhibitors
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Isoenzymes
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Neoplasm Proteins
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Solutions
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Sulfonamides
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antimony pentafluoride
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Antimony
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Carbonic Anhydrases
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Fluorides
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Hydrofluoric Acid